OPTIMIZATION OF ZINC BALANCE AT NEWBORNS WITH INTRAUTERINE GROWTH RETARDATION

L. Turova; T. Yaschenko, 6th- year student

Scientific supervisor – M.D. Markevich

Sumy State University, Department of Pediatrics with Medical Genetics

 

Today the problem of intrauterine growth retardation is very important. Various factors, including level of microelements cause this pathology. Zinc is one of most important microelements of the human body which deficiency during pregnancy negatively affects fetus.

The zinc disbalance in a fetus organism comes owing to infringement of its absorption in a digestive system and as at its raised deducing with urine.

Infringement of level of zinc along with increase of metabolic processes and functional immaturity of organs and systems of newborns with intrauterine growth retardation (IUGR) demands search of correction of that problem.

In this research influence of medicine, called «Drops of Beresh plus» on newborns with IUGR which had a zinc disbalance has been studied.

Peripheral venous blood of children with IUGR taken in the morning on an empty stomach was used as the material for research. After centrifugation the content of Zn was investigated separately in serum and erythrocytes. The content of Zn was defined by the method of atomic absorbed spectrophotometry on C115M1 spectrophotometer produced by JSC "Selmi" (Ukraine) and equipped with a computer program for automatic identification of the content items in samples. The level of zinc was controlled at the beginning and the end of treatment.

The research was carried out according to the international bioethical standards as for the parents’ agreement for their child to be examined.

Analysis of the obtained results was performed by means of the program called “Statistics 6.0”. Methods of varied statistics suitable for medical biological research were used. An average (M) and arithmetic average error (m) were defined. Reliable index of R was estimated by means of Student’s criterion (t).

It should be noted that introduction of “Beresh Drops Plus” into the course of rehabilitation therapy for infants with IUGR contributed to the positive dynamics of weight increase during the first months of life. The results of questioning of mothers showed that due to the use of the drug positive changes in behavioral reactions and more rapid restoration of sucking reflex appeared. The majority of children were observed to have improved the general state; they demonstrated reduced syndrome of nervous and reflexive excitability, and sleep resetting. None of the complications and side effects was observed during the course of using “Beresh Drops Plus”.

We identified that loss of zinc in the urine depended on gestational age and maturity of the newborn - the lower the indices were, the higher was the level of zinc in the urine which was likely to be related with functional immaturity of the urinary system. The proposed method of correction positively influenced the excretion of zinc – its (р<0,01) decrease in particular. The defined features seem to be a manifestation of zinc saving effect under the influence of the medication mentioned above.

So, usage of "Beresh Drops Plus” contributed to the increase of zinc level in serum and erythrocytes (p<0,001), and its decrease in urine on the contrary (р<0,001). Therefore, we consider this method of correction to be of great importance as it provides an optimal absorption of zinc by newborns with IUGR.